UNIT 11.1 An Introduction to the Informatics of “Next-Generation” Sequencing

  1. Lincoln D. Stein

Published Online: 1 DEC 2011

DOI: 10.1002/0471250953.bi1101s36

Current Protocols in Bioinformatics

Current Protocols in Bioinformatics

How to Cite

Stein, L. D. 2011. An Introduction to the Informatics of “Next-Generation” Sequencing. Current Protocols in Bioinformatics. 36:11.1:11.1.1–11.1.9.

Author Information

  1. Ontario Institute for Cancer Research, Toronto, Ontario, Canada

Publication History

  1. Published Online: 1 DEC 2011
  2. Published Print: DEC 2011


Next-generation sequencing (NGS) packs the sequencing throughput of a 2000's-era genome center into a single affordable machine. However, software developed for conventional sequencing technologies is often inadequate to deal with the nature of NGS technologies, which produce short, massively parallel reads. This unit surveys the software packages that are available for managing and analyzing NGS data. Curr. Protoc. Bioinform. 36:11.1.1-11.1.9. © 2011 by John Wiley & Sons, Inc.


  • “next generation”;
  • genome;
  • sequencing;
  • bioinformatics;
  • analysis