UNIT 12.1 An Overview of RNA Structure Prediction
Published Online: 1 FEB 2004
Copyright © 2003 by John Wiley and Sons, Inc.
Lab Protocol Title
Current Protocols in Bioinformatics
How to Cite
Stormo, G. D. 2004. An Overview of RNA Structure Prediction. Current Protocols in Bioinformatics. 12:12.1.
- Published Online: 1 FEB 2004
- Published Print: DEC 2003
This is not the most recent version of the article. View current version (15 OCT 2013)
This unit briefly describes the two fundamentally different methods for predicting RNA structures. The first is to find that structure with the minimum free energy of folding, as predicted by various thermodynamic parameters related to base-pair stacking, loop lengths, and other features. If one has only a single sequence, this thermodynamic approach is the best available method. The second fundamental approach to RNA structure prediction is to use multiple, homologous sequences for which one can infer a common structure, and then try and predict a structure common to all of the sequences. Such an approach is referred to as a comparative method or phylogenetic method of RNA structure prediction.