UNIT 12.5 Annotating Non-Coding RNAs with Rfam

  1. Sam Griffiths-Jones

Published Online: 1 APR 2005

DOI: 10.1002/0471250953.bi1205s9

Current Protocols in Bioinformatics

Current Protocols in Bioinformatics

How to Cite

Griffiths-Jones, S. 2005. Annotating Non-Coding RNAs with Rfam. Current Protocols in Bioinformatics. 9:12.5:12.5.1–12.5.12.

Author Information

  1. Wellcome Trust Sanger Institute Wellcome Trust Genome Campus, Hinxton, Cambridgeshire, United Kingdom

Publication History

  1. Published Online: 1 APR 2005
  2. Published Print: MAR 2005


Non-coding RNA (ncRNA) genes produce a functional RNA product, rather than a translated protein. The range and importance of such genes is only recently apparent, with known ncRNAs participating in a wide range of structural, regulatory, and catalytic roles within the cell. Like protein-coding genes, multiple sequence alignments of families of ncRNAs tell us much about their structure and function, and enable the formulation of statistical models for the detection of related sequences. Rfam is a database of families of ncRNAs, represented by structure-annotated multiple sequence alignments and covariance models.


  • non-coding RNA;
  • multiple sequence alignment;
  • genome annotation