Unit
UNIT 12.7 Identifying Structural Noncoding RNAs Using RNAz
Published Online: 1 SEP 2007
DOI: 10.1002/0471250953.bi1207s19
Copyright © 2007 by John Wiley and Sons, Inc.
Lab Protocol Title
Current Protocols in Bioinformatics
Additional Information
How to Cite
Washietl, S. and L. Hofacker, I. 2007. Identifying Structural Noncoding RNAs Using RNAz. Current Protocols in Bioinformatics. 19:12.7:12.7.1–12.7.18.
Publication History
- Published Online: 1 SEP 2007
- Published Print: SEP 2007
- Abstract
- Article
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Abstract
The functions of many noncoding RNAs and cis-acting regulatory elements of mRNAs depend on a defined RNA secondary structure. RNAz predicts such functional RNA structures on the basis of thermodynamic stability and evolutionary conservation of homologous sequences. It can be used to efficiently filter multiple alignments for noncoding RNA candidates in genomic screens. Curr. Protoc. Bioinform. 19:12.7.1-12.7.18. © 2007 by John Wiley & Sons, Inc.
Keywords:
- RNA structure;
- noncoding RNA;
- structure conservation;
- comparative genomics;
- gene prediction
