Unit

UNIT 12.7 Identifying Structural Noncoding RNAs Using RNAz

  1. Stefan Washietl,
  2. Ivo L. Hofacker

Published Online: 1 SEP 2007

DOI: 10.1002/0471250953.bi1207s19

Current Protocols in Bioinformatics

Current Protocols in Bioinformatics

How to Cite

Washietl, S. and L. Hofacker, I. 2007. Identifying Structural Noncoding RNAs Using RNAz. Current Protocols in Bioinformatics. 19:12.7:12.7.1–12.7.18.

Author Information

  1. University of Vienna, Vienna, Austria

Publication History

  1. Published Online: 1 SEP 2007
  2. Published Print: SEP 2007

Abstract

The functions of many noncoding RNAs and cis-acting regulatory elements of mRNAs depend on a defined RNA secondary structure. RNAz predicts such functional RNA structures on the basis of thermodynamic stability and evolutionary conservation of homologous sequences. It can be used to efficiently filter multiple alignments for noncoding RNA candidates in genomic screens. Curr. Protoc. Bioinform. 19:12.7.1-12.7.18. © 2007 by John Wiley & Sons, Inc.

Keywords:

  • RNA structure;
  • noncoding RNA;
  • structure conservation;
  • comparative genomics;
  • gene prediction