Unit

UNIT 14.7 PharmGKB: An Integrated Resource of Pharmacogenomic Data and Knowledge

  1. Li Gong1,
  2. Ryan P. Owen1,
  3. Winston Gor1,
  4. Russ B. Altman1,2,
  5. Teri E. Klein1

Published Online: 1 SEP 2008

DOI: 10.1002/0471250953.bi1407s23

Current Protocols in Bioinformatics

Current Protocols in Bioinformatics

How to Cite

Gong, L., Owen, R. P., Gor, W., Altman, R. B. and Klein, T. E. 2008. PharmGKB: An Integrated Resource of Pharmacogenomic Data and Knowledge. Current Protocols in Bioinformatics. 23:14.7:14.7.1–14.7.17.

Author Information

  1. 1

    Genetics Department, Stanford University, Stanford, California

  2. 2

    Department of Bioengineering, Stanford University, Stanford, California

Publication History

  1. Published Online: 1 SEP 2008
  2. Published Print: SEP 2008

Abstract

The PharmGKB is a publicly available online resource that aims to facilitate understanding how genetic variation contributes to variation in drug response. It is not only a repository of pharmacogenomics primary data, but it also provides fully curated knowledge including drug pathways, annotated pharmacogene summaries, and relationships among genes, drugs, and diseases. This unit describes how to navigate the PharmGKB Web site to retrieve detailed information on genes and important variants, as well as their relationship to drugs and diseases. It also includes protocols on our drug-centered pathway, annotated pharmacogene summaries, and our Web services for downloading the underlying data. Workflow on how to use PharmGKB to facilitate design of the pharmacogenomic study is also described in this unit. Curr. Protoc. Bioinform. 23:14.7.1-14.7.17. © 2008 by John Wiley & Sons, Inc.

Keywords:

  • database;
  • pharmacogenomics;
  • pharmacogenetics;
  • drug response;
  • genetic variation;
  • pathway analysis;
  • SNP;
  • polymorphisms;
  • study design