UNIT 15.5 Using SomaticSniper to Detect Somatic Single Nucleotide Variants

  1. David E. Larson,
  2. Travis E. Abbott,
  3. Richard K. Wilson

Published Online: 21 MAR 2014

DOI: 10.1002/0471250953.bi1505s45

Current Protocols in Bioinformatics

Current Protocols in Bioinformatics

How to Cite

Larson, D. E., Abbott, T. E. and Wilson, R. K. 2014. Using SomaticSniper to Detect Somatic Single Nucleotide Variants. Current Protocols in Bioinformatics. 15:15.5:15.5.1–15.5.8.

Author Information

  1. The Genome Institute at Washington University, St. Louis, Missouri

Publication History

  1. Published Online: 21 MAR 2014


Detecting somatic single nucleotide variants (SNVs) is an essential component of cancer research with next-generation sequencing data. This unit describes how to run the SomaticSniper somatic SNV detector and then filter the output to eliminate most false positives. It also includes support protocols detailing the compilation of the software. Curr. Protoc. Bioinform. 45:15.5.1-15.5.8. © 2014 by John Wiley & Sons, Inc.


  • next-generation sequencing;
  • somatic variant calling;
  • SomaticSniper