Standard Article

Inhalation Toxicity

  1. Juergen Pauluhn

Published Online: 15 APR 2003

DOI: 10.1002/047126363X.agr142

Encyclopedia of Agrochemicals

Encyclopedia of Agrochemicals

How to Cite

Pauluhn, J. 2003. Inhalation Toxicity. Encyclopedia of Agrochemicals. .

Author Information

  1. Bayer AG, Wuppertal, Germany

Publication History

  1. Published Online: 15 APR 2003

Abstract

Several animal models have traditionally been used in inhalation studies with pesticides. Especially in inhalation toxicity, the introduction of new animal models is usually a very slow and involved process, as respective baseline data are not yet available and, due to the number of variables involved, the validation of novel exposure systems or new animal models is commonly more elaborate when compared with other routes. Moreover, experimental animals may experience exposure-related stress and ensuing physiological response following inhalation to local irritants, which may be absent following other routes. Therefore, the selection of the most appropriate test animal model for an inhalation toxicity study is not a simple matter.

Keywords:

  • inhalation studies;
  • route-to-route extrapolation;
  • pesticide aerosols;
  • inhalation toxicity tests;
  • respiratory tract;
  • irritants