Published Online: 15 APR 2003
Copyright © 2003 by John Wiley & Sons, Inc. All rights reserved.
Encyclopedia of Agrochemicals
How to Cite
Pauluhn, J. 2003. Inhalation Toxicity. Encyclopedia of Agrochemicals. .
- Published Online: 15 APR 2003
Several animal models have traditionally been used in inhalation studies with pesticides. Especially in inhalation toxicity, the introduction of new animal models is usually a very slow and involved process, as respective baseline data are not yet available and, due to the number of variables involved, the validation of novel exposure systems or new animal models is commonly more elaborate when compared with other routes. Moreover, experimental animals may experience exposure-related stress and ensuing physiological response following inhalation to local irritants, which may be absent following other routes. Therefore, the selection of the most appropriate test animal model for an inhalation toxicity study is not a simple matter.
- inhalation studies;
- route-to-route extrapolation;
- pesticide aerosols;
- inhalation toxicity tests;
- respiratory tract;