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MALDI

  1. M. F. Wilson,
  2. J. R. Startin

Published Online: 15 APR 2003

DOI: 10.1002/047126363X.agr158

Encyclopedia of Agrochemicals

Encyclopedia of Agrochemicals

How to Cite

Wilson, M. F. and Startin, J. R. 2003. MALDI. Encyclopedia of Agrochemicals. .

Author Information

  1. Central Science Laboratory, Sand Hutton, York, United Kingdom

Publication History

  1. Published Online: 15 APR 2003

Abstract

Matrix-assisted laser desorption/ionization (MALDI) is a specialized sample introduction and ionization technique for mass spectrometry (MS). Following its announcement by Hillenkamp and Karas in 1988, MALDI was quickly recognized as a major new weapon in the armory of chemists and biochemists for measurement of the molecular weights of large molecules. MALDI has been most widely and most successfully applied to the study of proteins and peptides, but it has also proved useful for other types of biomolecules, for synthetic polymers, and to a lesser extent, for lower molecular weight compounds.

Keywords:

  • matrix-assisted laser desorption/ionization (MALDI);
  • mass spectrometry;
  • molecular weight compounds;
  • time-of-flight;
  • biomolecules;
  • synthetic polymers;
  • fourier transform-ion cyclotron resonance;
  • mass spectrometers