The Reformatsky Reaction
Published Online: 15 MAR 2011
Copyright © 2003 John Wiley & Sons, Inc. All rights reserved.
How to Cite
Shriner, R. L. 2011. The Reformatsky Reaction. Organic Reactions. 1:1:1–37.
- Published Online: 15 MAR 2011
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The reaction which takes place between a carbonyl compound such as an aldehyde, ketone, or an ester, and an alpha-haloester in the presence of zinc is commonly known as the Reformatsky reaction. It represents an extension of the reactions of carbonyl compounds with a dialkylzinc or an alkylzinc halide, but possesses the advantage that the isolation of the organozinc compound is unnecessary. The process creates a new carbon-carbon linkage and involves the following: Formation of an organozinc halide; addition to the carbonyl group of the aldehyde or ketone, decomposition by dilute acids.
- Reformatsky reaction;
- side reactions;
- halogen compounds;
- carbon chain;
- arylacetic acids;
- experimental conditions