Chloromethylation of Aromatic Compounds
Published Online: 15 MAR 2011
Copyright © 2004 by Organic Reactions, Inc. Published by John Wiley & Sons, Inc.
How to Cite
Fuson, R. C. and McKeever, C. H. 2011. Chloromethylation of Aromatic Compounds. Organic Reactions. 1:3:63–90.
- Published Online: 15 MAR 2011
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The replacement of a hydrogen atom by a chloromethyl group in a single operation has come to be known as chloromethylation. The process is illustrated by its earliest example, a synthesis of benzyl chloride carried out by Grassi and Maselli. This chapter is limited to nuclear chloromethylation of aromatic compounds. Typical procedures are given and an attempt is made to indicate the scope and limitations of the reaction.
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