The Preparation of Unsymmetrical Biaryls by the Diazo Reaction and the Nitrosoacetylamine Reaction
Published Online: 15 MAR 2011
Copyright © 2004 by Organic Reactions, Inc. Published by John Wiley & Sons, Inc.
How to Cite
Bachmann, W. E. and Hoffman, R. A. 2011. The Preparation of Unsymmetrical Biaryls by the Diazo Reaction and the Nitrosoacetylamine Reaction. Organic Reactions. 2:6:224–261.
- Published Online: 15 MAR 2011
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The amino group of aromatic amines can be replaced by aryl groups with the formation of unsymmetrical biaryl by two general procedures: (1) by reaction of the aryldiazo hydroxide or acetate with aromatic compounds and (2) by reaction of the nitrosoacetylamine with aromatic compounds, In general the aromatic compounds must be a liquid for no solvent has been found which will not be attacked by the reactive intermediates which are formed in these reactions. Diazo and nirosoacetykeamine reactions are discussed.
- diazo reaction;
- unsymmetrical biaryls;
- nitrosoacetylamine reaction;
- arylthiophenes Arylpyridines;
- side reactions;
- experimental conditions