The Preparation of Amines by Reductive Alkylation
Published Online: 15 MAR 2011
Copyright © 2004 by Organic Reactions, Inc. Published by John Wiley & Sons, Inc.
How to Cite
Emerson, W. S. 2011. The Preparation of Amines by Reductive Alkylation. Organic Reactions. 4:3:174–255.
- Published Online: 15 MAR 2011
Reductive alkylation is the term applied to the process of introducing alkyl groups into ammonia or primary or secondary amine by means of an aldehdye or ketone in the presence of a reducing agent. This chapter is limited to those reductive alkylations in which the reducing agent is hydrogen and a catalysts or nascent hydrogen, usually from a metal-acid combination; most of these reductive alkylations have been carried out with hydrogen and a catalyst.
- reductive alkylation;
- Schiff's base;
- primary amines;
- secondary amines;
- tertiary amines;
- experimental conditions