Standard Article

The Preparation of Amines by Reductive Alkylation

  1. William S. Emerson

Published Online: 15 MAR 2011

DOI: 10.1002/0471264180.or004.03

Organic Reactions

Organic Reactions

How to Cite

Emerson, W. S. 2011. The Preparation of Amines by Reductive Alkylation. Organic Reactions. 4:3:174–255.

Author Information

  1. Monsanto Chemical Company Dayton, Ohio

Publication History

  1. Published Online: 15 MAR 2011


Reductive alkylation is the term applied to the process of introducing alkyl groups into ammonia or primary or secondary amine by means of an aldehdye or ketone in the presence of a reducing agent. This chapter is limited to those reductive alkylations in which the reducing agent is hydrogen and a catalysts or nascent hydrogen, usually from a metal-acid combination; most of these reductive alkylations have been carried out with hydrogen and a catalyst.


  • amines;
  • reductive alkylation;
  • aldehdyes;
  • ketones;
  • ammonia;
  • Schiff's base;
  • primary amines;
  • secondary amines;
  • tertiary amines;
  • experimental conditions