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The Rosenmund Reduction of Acid Chlorides to Aldehydes

  1. Erich Mosettig1,
  2. Ralph Mozingo2

Published Online: 15 MAR 2011

DOI: 10.1002/0471264180.or004.07

Organic Reactions

Organic Reactions

How to Cite

Mosettig, E. and Mozingo, R. 2011. The Rosenmund Reduction of Acid Chlorides to Aldehydes. Organic Reactions. 4:7:362–377.

Author Information

  1. 1

    National Institute of Health, U. S. Public Health Service

  2. 2

    Merck and Company, Inc.

Publication History

  1. Published Online: 15 MAR 2011

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Abstract

In the synthesis of complex molecules, particularly in connection with natural products, it is occasionally desirable to prepare an aldehyde when the readily available starting material is the corresponding acid. The Rosenmund reduction is probably the most useful method for application to a large number of aldehdyes of varied types. The Rosenmund reduction consists in the selective hydrogenation of an acid chloride in the presence of a suitable catalyst, usually supported palladium to the corresponding aldehyde.

Keywords:

  • Rosenmund reduction;
  • acid chlorides;
  • aldehydes;
  • catalyst;
  • regulator;
  • solvent;
  • hydrogen;
  • precautions;
  • experimental procedures