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The Gattermann-Koch Reaction

  1. Nathan N. Crounse

Published Online: 15 MAR 2011

DOI: 10.1002/0471264180.or005.06

Organic Reactions

Organic Reactions

How to Cite

Crounse, N. N. 2011. The Gattermann-Koch Reaction . Organic Reactions. 5:6:290–300.

Author Information

  1. The Hilton-Davis Chemical Company

Publication History

  1. Published Online: 15 MAR 2011

Chemistry Terms

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Abstract

The introduction of an aldehyde group into certain aromatic nuclei by means of carbon monoxide, hydrogen chloride, and an appropriate catalyst is know as the Gatterman-Koch reaction. The catalyst commonly used is aluminum chloride with cuprous chloride as a carrier. The carrier is not necessary when high pressure is used. Gatterman discovered the reaction when he tried to extend the Friedel-Crafts reaction to the hypothetical formyl chloride.

Keywords:

  • Gatterman-Koch reaction;
  • catalyst;
  • aluminum chloride;
  • benzaldehyde;
  • formylation;
  • carriers;
  • experimental procedures