The Preparation of Thiazoles
Published Online: 15 MAR 2011
Copyright © 2004 by Organic Reactions, Inc. Published by John Wiley & Sons, Inc.
How to Cite
Wiley, R. H., England, D. C. and Behr, L. C. 2011. The Preparation of Thiazoles. Organic Reactions. 6:8:367–409.
- Published Online: 15 MAR 2011
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Thiazoles have become increasingly important in pharmaceutical, biochemical and technical fields. Commercially important compounds that contain the thiazole ring are the mercaptothiazoles, which are valuable as rubber accelerators, and for penicillins and thiamin, for example. Certain thiazole derivatives show great promise as intermediates in the synthesis of amino acids. This chapter summarizes information on the methods of preparation of the thiazoles, but is restricted to those in which the thiazole ring is not part of a condensed system.
- halo carbonyl compounds;
- ammonium dithiocarbamate;
- thiocyano ketones;
- phosphorus pentasulfide;
- acylamino carbonyl compounds;
- experimental conditions