Standard Article

The Preparation of Thiazoles

  1. Richard H. Wiley1,
  2. D. C. England2,
  3. Lyell C. Behr3

Published Online: 15 MAR 2011

DOI: 10.1002/0471264180.or006.08

Organic Reactions

Organic Reactions

How to Cite

Wiley, R. H., England, D. C. and Behr, L. C. 2011. The Preparation of Thiazoles. Organic Reactions. 6:8:367–409.

Author Information

  1. 1

    University of Louisville

  2. 2

    E. I. du Pont de Nemours and Company

  3. 3

    Mississippi State College

Publication History

  1. Published Online: 15 MAR 2011

Chemistry Terms

Choose one or more boxes to highlight terms.


Thiazoles have become increasingly important in pharmaceutical, biochemical and technical fields. Commercially important compounds that contain the thiazole ring are the mercaptothiazoles, which are valuable as rubber accelerators, and for penicillins and thiamin, for example. Certain thiazole derivatives show great promise as intermediates in the synthesis of amino acids. This chapter summarizes information on the methods of preparation of the thiazoles, but is restricted to those in which the thiazole ring is not part of a condensed system.


  • thiazoles;
  • halo carbonyl compounds;
  • ammonium dithiocarbamate;
  • thioamides;
  • thiocyano ketones;
  • phosphorus pentasulfide;
  • acylamino carbonyl compounds;
  • experimental conditions