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The Synthesis of Ketones from Acid Halides and Organometallic Compounds of Magnesium, Zinc, and Cadmium

  1. David A. Shirley*

Published Online: 15 MAR 2011

DOI: 10.1002/0471264180.or008.02

Organic Reactions

Organic Reactions

How to Cite

Shirley, D. A. 2011. The Synthesis of Ketones from Acid Halides and Organometallic Compounds of Magnesium, Zinc, and Cadmium. Organic Reactions. 8:2:28–58.

Author Information

  1. Tulane University of Louisiana

  1. *

    Present address: University of Tennessee.

Publication History

  1. Published Online: 15 MAR 2011

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Abstract

The synthesis of ketones from acid halides and organometallic compounds may be represented by the following equation:

original image

Freund fist observed the formation of ketones from simple acid chlorides and dimethyl- and diethyl-zinc. Organometallic compounds of sodium, copper, magnesium, cadmium, mercury, aluminum, tin, and lead have also been found to give this reaction. Only organozinc, organocadmium, and organomagnesium reagents have been found to be generally useful for such syntheses, however. These reactions are reviewed in this chapter.

Keywords:

  • ketones;
  • acid halides;
  • organometallic zinc;
  • organometallic cadmium;
  • organometallic magnesium;
  • grignard reagents;
  • other syntheses;
  • experimental procedures