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The Baeyer-Villiger Oxidation of Aldehydes and Ketones

  1. C. H. Hassall

Published Online: 15 MAR 2011

DOI: 10.1002/0471264180.or009.03

Organic Reactions

Organic Reactions

How to Cite

Hassall, C. H. 2011. The Baeyer-Villiger Oxidation of Aldehydes and Ketones. Organic Reactions. 9:3:73–106.

Author Information

  1. University College of the West Indies, Jamaica

Publication History

  1. Published Online: 15 MAR 2011

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Abstract

In 1899, Bayer and Vlliger showed that the oxidation of alicyclic ketones, menthone, tetrahydrocarvone, and camphor with permono-sulfuric acid led to the formation of lactones. Further studies using a variety of ketones or aldehydes and hydrogen peroxide or peracids in various media have established that the oxidation is of wide applicability. The oxidation, the Baeyer-Villiger reaction, is the subject of this review. As the oxidation normally employs mild conditions, gives reasonable yields, and shows a high degree of selectivity, it has proved useful in a variety of both synthetic and degradative studies. Recent investigations have led to a better definition of favorable experimental conditions and have extended the scope of the reaction.

Keywords:

  • Baeyer-Villiger oxidation;
  • aldehdyes;
  • ketones;
  • polycarbonyl compounds;
  • side reactions;
  • experimental conditions;
  • procedures