The Reformatsky Reaction
Published Online: 15 MAR 2011
Copyright © 2004 by Organic Reactions, Inc. Published by John Wiley & Sons, Inc.
How to Cite
Rathke, M. W. 2011. The Reformatsky Reaction. Organic Reactions. 22:4:423–460.
- Published Online: 15 MAR 2011
The Reformatsky reaction is the reaction of a carbonyl compound, usually an aldehyde or a ketone, with an alpha-haloester in the presence of zinc metal to furnish, after hydrolysis, a β-hydoxyester. Subsequent dehydration of the hydroxyester is commonly carried out to form an alpha, β-unsaturated ester. This chapter summarizes some of the more important advances in the understanding and use of the Reformatsky reaction since the original chapter was published in volume 1 of this series.
- Reformatsky reaction;
- side reactions;
- two-step procedures;
- comparisons with other methods;
- experimental procedures