Chapter 4. Iron-Containing Oxygen Carriers and Their Synthetic Models
Published Online: 19 MAR 2003
DOI: 10.1002/0471265330.ch4
Copyright © 2002 John Wiley & Sons, Inc.
Book Title
Bioinorganic Chemistry: A Short Course
Additional Information
How to Cite
Roat-Malone, R. M. (2003) Iron-Containing Oxygen Carriers and Their Synthetic Models, in Bioinorganic Chemistry: A Short Course, John Wiley & Sons, Inc., Hoboken, NJ, USA. doi: 10.1002/0471265330.ch4
Publication History
- Published Online: 19 MAR 2003
- Published Print: 20 SEP 2002
ISBN Information
Print ISBN: 9780471159766
Online ISBN: 9780471265337
- Summary
- Chapter
Keywords:
- iron-containing oxygen carriers;
- synthetic models;
- myoglobin;
- hemoglobin;
- prosthetic group;
- analytical techniques;
- reversible binding;
- dioxygen;
- cooperativity;
- oxygen binding
Summary
Chemists began working on model compounds for myoglobin and hemoglobin in the early 1970s. The discussion in this chapter will be on: (1) structure of the active heme site of myoglobin and hemoglobin as determined by NMR, X-ray crystallography, and other methods; (2) analytical techniques used to study Mb and Hb; (3) the mechanism for reversible binding of dioxygen and cooperativity of oxygen binding; (4) structure of the active site in Mb and Hb compared to that in model compounds; and (5) the selectivity of Mb and Hb for O2 versus CO binding.