Chapter 4. Iron-Containing Oxygen Carriers and Their Synthetic Models

  1. Rosette M. Roat-Malone

Published Online: 19 MAR 2003

DOI: 10.1002/0471265330.ch4

Bioinorganic Chemistry: A Short Course

Bioinorganic Chemistry: A Short Course

How to Cite

Roat-Malone, R. M. (2002) Iron-Containing Oxygen Carriers and Their Synthetic Models, in Bioinorganic Chemistry: A Short Course, John Wiley & Sons, Inc., Hoboken, NJ, USA. doi: 10.1002/0471265330.ch4

Author Information

  1. Washington College, Chestertown, MD, USA

Publication History

  1. Published Online: 19 MAR 2003
  2. Published Print: 20 SEP 2002

ISBN Information

Print ISBN: 9780471159766

Online ISBN: 9780471265337

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Keywords:

  • iron-containing oxygen carriers;
  • synthetic models;
  • myoglobin;
  • hemoglobin;
  • prosthetic group;
  • analytical techniques;
  • reversible binding;
  • dioxygen;
  • cooperativity;
  • oxygen binding

Summary

Chemists began working on model compounds for myoglobin and hemoglobin in the early 1970s. The discussion in this chapter will be on: (1) structure of the active heme site of myoglobin and hemoglobin as determined by NMR, X-ray crystallography, and other methods; (2) analytical techniques used to study Mb and Hb; (3) the mechanism for reversible binding of dioxygen and cooperativity of oxygen binding; (4) structure of the active site in Mb and Hb compared to that in model compounds; and (5) the selectivity of Mb and Hb for O2 versus CO binding.