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Anti-Inflammatory Steroids

  1. Mitchell A. Avery,
  2. John R. Woolfrey

Published Online: 15 JAN 2003

DOI: 10.1002/0471266949.bmc056

Burger's Medicinal Chemistry and Drug Discovery

Burger's Medicinal Chemistry and Drug Discovery

How to Cite

Avery, M. A. and Woolfrey, J. R. 2003. Anti-Inflammatory Steroids. Burger's Medicinal Chemistry and Drug Discovery. 747–854.

Author Information

  1. University of Mississippi University, Department of Medicinal Chemistry School of Pharmacy, University, Mississippi, USA

Publication History

  1. Published Online: 15 JAN 2003

Abstract

We know today that structural changes in steroids can bring about potency alterations in animal pharmacology through a number of mechanisms. The processes that are affected include pharmacokinetic parameters such as drug absorption and drug distribution, as well as drug metabolism to more or less active metabolites. There is now a large body of literature dealing with these phenomena that makes predictive thinking possible in these areas. Other mechanisms that are involved in the effect of structural changes on pharmacological activity in steroids include the effect of steroid structure on receptor affinity and the manner in which changes in the steroid agonist affect intrinsic activity through alterations in gene expression. These and other concepts relating to anti-inflammatory steroids are discussed in this chapter.

Keywords:

  • anti-inflammatory steroids;
  • clinical use;
  • adverse effects;
  • absorption;
  • drug distribution;
  • glucocorticoid biosynthesis;
  • drug receptor affinity;
  • structural change;
  • antiglucocorticoids;
  • nonsteroidal glucocorticoids