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Agents Acting on Prostanoid and Thromboxane Receptors

Pulmonary, Bone, Vitamins and Autocoid Therapeutic Agents

  1. Adrian Hall1,2,
  2. Simon Peace3,
  3. Martin E. Swarbrick1,4

Published Online: 15 SEP 2010

DOI: 10.1002/0471266949.bmc064.pub2

Burger's Medicinal Chemistry and Drug Discovery

Burger's Medicinal Chemistry and Drug Discovery

How to Cite

Hall, A., Peace, S. and Swarbrick, M. E. 2010. Agents Acting on Prostanoid and Thromboxane Receptors. Burger's Medicinal Chemistry and Drug Discovery. 791–944.

Author Information

  1. 1

    GlaxoSmithKline, New Frontiers Science Park,Harlow, Neurosciences Centre of Excellence for Drug Discovery, Essex, UK

  2. 2

    Neuroscience Product Creation Unit, Eisai Limited, European Knowledge Centre, Hatfield, Hertfordshire, UK

  3. 3

    GlaxoSmithKline, Medicines Research Centre, Respiratory Centre of Excellence for Drug Discovery, Stevenage, UK

  4. 4

    Cancer Research Technology Ltd, Discovery Laboratory, Cambridge, UK

Publication History

  1. Published Online: 15 SEP 2010

Abstract

This chapter covers recent developments in the prostaglandin and thromboxane research area, with particular focus on the medicinal chemistry aspects. Each of the receptors is discussed in turn with progress and medicinal chemistry strategies discussed for both agonists and antagonists. Clinical development compounds are highlighted.

Keywords:

  • prostaglandins;
  • thromboxane;
  • antagonist;
  • agonist;
  • eicosanoid