Standard Article


  1. C. T. Peng

Published Online: 15 JAN 2003

DOI: 10.1002/0471266949.bmc069

Burger's Medicinal Chemistry and Drug Discovery

Burger's Medicinal Chemistry and Drug Discovery

How to Cite

Peng, C. T. 2003. Radiopaques. Burger's Medicinal Chemistry and Drug Discovery. 473–588.

Author Information

  1. University of California, Department of Pharmaceutical Chemistry, School of Pharmacy, San Francisco, California, USA

Publication History

  1. Published Online: 15 JAN 2003


This review discusses radiopaques from research and development to application. Radiopaques attenuate X-rays and may be either high atomic-numbered materials or iodinated organic compounds. The latter may appear sometimes in liposomes or particulates. The theoretical and historical aspects, classification by structures, methods of synthesis, structure-activity relationship, physical, chemical, and pharmacological properties, and related reactions, essential to the understanding of safety, tolerability, and efficacy of radiopaques in medical use, are included in the discussion.


  • X-rays;
  • radiopaques;
  • iodinated organic compounds;
  • high osmolality contrast media (HOCM);
  • low osmolality contrast media (LOCM);
  • adverse reactions;
  • computed tomography (CT);
  • structure-activity relationship