Published Online: 15 JAN 2003
Copyright © 2003 by John Wiley & Sons, Inc. All rights reserved.
Burger's Medicinal Chemistry and Drug Discovery
How to Cite
Peng, C. T. 2003. Radiopaques. Burger's Medicinal Chemistry and Drug Discovery. 473–588.
- Published Online: 15 JAN 2003
This review discusses radiopaques from research and development to application. Radiopaques attenuate X-rays and may be either high atomic-numbered materials or iodinated organic compounds. The latter may appear sometimes in liposomes or particulates. The theoretical and historical aspects, classification by structures, methods of synthesis, structure-activity relationship, physical, chemical, and pharmacological properties, and related reactions, essential to the understanding of safety, tolerability, and efficacy of radiopaques in medical use, are included in the discussion.
- iodinated organic compounds;
- high osmolality contrast media (HOCM);
- low osmolality contrast media (LOCM);
- adverse reactions;
- computed tomography (CT);
- structure-activity relationship