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Anthelmintics

  1. Robert K. Griffith

Published Online: 15 JAN 2003

DOI: 10.1002/0471266949.bmc092

Burger's Medicinal Chemistry and Drug Discovery

Burger's Medicinal Chemistry and Drug Discovery

How to Cite

Griffith, R. K. 2003. Anthelmintics. Burger's Medicinal Chemistry and Drug Discovery. 1090–1096.

Author Information

  1. West Virginia University, School of Pharmacy, Morgantown, West Virginia, USA

Publication History

  1. Published Online: 15 JAN 2003

Abstract

This chapter discusses the agents currently available for the treatment of helmintic infections in humans. Current therapy for helmintic infections is dominated by praziquantel, benzimidazoles, and ivermectin. Praziquantel is the drug of choice for trematode infections including all types of schistosomiasis and various flukes. Ivermectin is the drug of choice for onchocerciasis and most other forms of filariasis, often used in combination with albendazole. Benzimidazoles are drugs of choice for most infections caused by nematodes. Unfortunately, no significant new classes of anthelmintic drugs have been introduced in nearly 20 years.

Keywords:

  • antischistosomals;
  • antifilarials;
  • onchocerciasis;
  • filariasis;
  • schistosomiasis;
  • benzimidazoles;
  • ivermectin