Adrenergics and Adrenergic-Blocking Agents
Published Online: 15 JAN 2003
Copyright © 2003 by John Wiley & Sons, Inc. All rights reserved.
Burger's Medicinal Chemistry, Drug Discovery and Development
How to Cite
Griffith, R. K. 2003. Adrenergics and Adrenergic-Blocking Agents. Burger's Medicinal Chemistry, Drug Discovery and Development. 1–37.
- Published Online: 15 JAN 2003
This chapter reviews the drugs currently available in the United States that exert their therapeutic effects through actions on α- and β-adrenoceptors and biosynthesis, release, and processing of the neurotransmitter norepinephrine. Included in the review are drugs acting as selective and nonselective agonists and antagonists at both α- and β-adrenoceptors, as well as drugs that interfere with norepinephrine biosynthesis and release. Therapeutic categories include antihypertensives, bronchodilators, antiglaucoma agents, vasopressors, and nasal decongestants. Structure-activity relationships are reviewed as are the structure and function of various adrenoceptors. Briefly covered is the metabolism of representative drugs in each structural class as well as recent developments in approaches to new drugs in the areas of selective α1A-antagonists for treatment of prostatic hypertrophy and selective β3-agonists for treatment of obesity and diabetes.
- nasal decongestants;
- drug metabolism;