Chapter 2. How Do Enzymes Work?

  1. Alejandro G. Marangoni
  1. Alejandro G. Marangoni

Published Online: 13 MAR 2003

DOI: 10.1002/0471267295.ch2

Enzyme Kinetics: A Modern Approach

Enzyme Kinetics: A Modern Approach

How to Cite

Marangoni, A. G. (2002) How Do Enzymes Work?, in Enzyme Kinetics: A Modern Approach (ed A. G. Marangoni), John Wiley & Sons, Inc., Hoboken, NJ, USA. doi: 10.1002/0471267295.ch2

Editor Information

  1. Department of Food Science, University of Guelph, Canada

Author Information

  1. Department of Food Science, University of Guelph, Canada

Publication History

  1. Published Online: 13 MAR 2003
  2. Published Print: 1 NOV 2002

ISBN Information

Print ISBN: 9780471159858

Online ISBN: 9780471267294

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Keywords:

  • transition-state binding;
  • rate constant;
  • energy of activation

Summary

The general mechanism of enzyme action is reviewed in this chapter. Transition-state theory arguments are utilized to highlight the fact that enzymes are designed to specifically bind to the transition-state of a chemical reaction, and thus stabilizing it. This stabilization of the transition-state leads to an increase in the rate of the reaction. Here we show how enzymatic rate acceleration is equivalent to the strength of transition-state binding.