Chapter 2. How Do Enzymes Work?
- Alejandro G. Marangoni
Published Online: 13 MAR 2003
DOI: 10.1002/0471267295.ch2
Copyright © 2003 John Wiley & Sons, Inc.
Book Title
Enzyme Kinetics: A Modern Approach
Additional Information
How to Cite
Marangoni, A. G. (2003) How Do Enzymes Work?, in Enzyme Kinetics: A Modern Approach (ed A. G. Marangoni), John Wiley & Sons, Inc., Hoboken, NJ, USA. doi: 10.1002/0471267295.ch2
Editor Information
Department of Food Science, University of Guelph, Canada
Publication History
- Published Online: 13 MAR 2003
- Published Print: 1 NOV 2002
ISBN Information
Print ISBN: 9780471159858
Online ISBN: 9780471267294
- Summary
- Chapter
Keywords:
- transition-state binding;
- rate constant;
- energy of activation
Summary
The general mechanism of enzyme action is reviewed in this chapter. Transition-state theory arguments are utilized to highlight the fact that enzymes are designed to specifically bind to the transition-state of a chemical reaction, and thus stabilizing it. This stabilization of the transition-state leads to an increase in the rate of the reaction. Here we show how enzymatic rate acceleration is equivalent to the strength of transition-state binding.