Chapter 5. Irreversible Enzyme Inhibition

  1. Alejandro G. Marangoni
  1. Alejandro G. Marangoni

Published Online: 13 MAR 2003

DOI: 10.1002/0471267295.ch5

Enzyme Kinetics: A Modern Approach

Enzyme Kinetics: A Modern Approach

How to Cite

Marangoni, A. G. (2002) Irreversible Enzyme Inhibition, in Enzyme Kinetics: A Modern Approach (ed A. G. Marangoni), John Wiley & Sons, Inc., Hoboken, NJ, USA. doi: 10.1002/0471267295.ch5

Editor Information

  1. Department of Food Science, University of Guelph, Canada

Author Information

  1. Department of Food Science, University of Guelph, Canada

Publication History

  1. Published Online: 13 MAR 2003
  2. Published Print: 1 NOV 2002

ISBN Information

Print ISBN: 9780471159858

Online ISBN: 9780471267294

SEARCH

Keywords:

  • irreversible inhibition;
  • Ki;
  • simple;
  • time-dependent

Summary

In this chapter, models for irreversible inhibition are derived from first principles for simple and time-dependent irreversible enzyme inhibition in the presence and absence of substrate. Differentiation between simple and time-dependent irreversible inhibition is also discussed.