Chapter 12. Study Designs
Published Online: 20 MAY 2003
DOI: 10.1002/0471308889.ch12
Copyright © 2003 John Wiley & Sons, Inc.
Book Title
Introductory Biostatistics
Additional Information
How to Cite
Le, C. T. (2003) Study Designs, in Introductory Biostatistics, John Wiley & Sons, Inc., Hoboken, NJ, USA. doi: 10.1002/0471308889.ch12
Publication History
- Published Online: 20 MAY 2003
- Published Print: 21 MAR 2003
ISBN Information
Print ISBN: 9780471418160
Online ISBN: 9780471308881
- Summary
- Chapter
Keywords:
- study design;
- retrospective study;
- prospective study;
- cohort design;
- retrospective study of past events;
- clinical trial;
- phase I;
- phase II;
- phase III;
- designing phase I trials;
- cohort-escalation trial;
- maximum-tolerated dose;
- sample size determination;
- continuous endpoint;
- design for selection;
- toxicity monitoring;
- proportional hazards model;
- planning of a clinical trial;
- sample size for a case-control study;
- design of a matched case-control study;
- logistic regression
Summary
In this chapter we focus on study designs. However, since in biomedical research, the sample survey is not a common form of study, and prospective studies of past events and cohort studies are not often conducted, we put more emphasis on the designs of clinical trials which are important because they are experiments on human beings, and of case-control studies, which are the most popular of all study designs. A problem solving section appears at the end of the chapter.