2. Transport Model

  1. Alex Avdeef

Published Online: 8 OCT 2003

DOI: 10.1002/047145026X.ch2

Absorption and Drug Development: Solubility, Permeability, and Charge State

Absorption and Drug Development: Solubility, Permeability, and Charge State

How to Cite

Avdeef, A. (2003) Transport Model, in Absorption and Drug Development: Solubility, Permeability, and Charge State, John Wiley & Sons, Inc., Hoboken, NJ, USA. doi: 10.1002/047145026X.ch2

Author Information

  1. pION, Inc., USA

Publication History

  1. Published Online: 8 OCT 2003
  2. Published Print: 15 AUG 2003

ISBN Information

Print ISBN: 9780471423652

Online ISBN: 9780471450269

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Keywords:

  • Fick's law;
  • diffusion;
  • gastrointestinal tract;
  • pH microclimate;
  • BCS

Summary

This chapter defines the flux model, based on Fick's laws of diffusion, in terms of solubility, permeability, and charge state (pH). Properties of the gastrointestinal tract, including regional pH variations, use of the octanol model, and how regulatory agencies use transport-related measured properties are covered. The coverage lays the foundation for the rest of the book.