Chapter 3. Charge State
Published Online: 8 OCT 2003
DOI: 10.1002/047145026X.ch3
Copyright © 2003 John Wiley & Sons, Inc.
Book Title
Absorption and Drug Development: Solubility, Permeability, and Charge State
Additional Information
How to Cite
Avdeef, A. (2003) Charge State, in Absorption and Drug Development: Solubility, Permeability, and Charge State, John Wiley & Sons, Inc., Hoboken, NJ, USA. doi: 10.1002/047145026X.ch3
Publication History
- Published Online: 8 OCT 2003
- Published Print: 15 AUG 2003
ISBN Information
Print ISBN: 9780471423652
Online ISBN: 9780471450269
- Summary
- Chapter
Keywords:
- pKa;
- Bjerrum plot;
- cosolvents;
- UV-based methods;
- CE-based methods
Summary
This chapter surveys the topic of ionization constants—how to measure pKas well and quickly, and which methods to use. Bjerrum analysis is revealed as the ‘secret’ weapon behind the most effective approaches. A list of ‘gold standard’ quality constants is compiled.