3. Charge State

  1. Alex Avdeef

Published Online: 8 OCT 2003

DOI: 10.1002/047145026X.ch3

Absorption and Drug Development: Solubility, Permeability, and Charge State

Absorption and Drug Development: Solubility, Permeability, and Charge State

How to Cite

Avdeef, A. (2003) Charge State, in Absorption and Drug Development: Solubility, Permeability, and Charge State, John Wiley & Sons, Inc., Hoboken, NJ, USA. doi: 10.1002/047145026X.ch3

Author Information

  1. pION, Inc., USA

Publication History

  1. Published Online: 8 OCT 2003
  2. Published Print: 15 AUG 2003

ISBN Information

Print ISBN: 9780471423652

Online ISBN: 9780471450269

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Keywords:

  • pKa;
  • Bjerrum plot;
  • cosolvents;
  • UV-based methods;
  • CE-based methods

Summary

This chapter surveys the topic of ionization constants—how to measure pKas well and quickly, and which methods to use. Bjerrum analysis is revealed as the ‘secret’ weapon behind the most effective approaches. A list of ‘gold standard’ quality constants is compiled.