Chapter 4. Partitioning into Octanol
Published Online: 8 OCT 2003
DOI: 10.1002/047145026X.ch4
Copyright © 2003 John Wiley & Sons, Inc.
Book Title
Absorption and Drug Development: Solubility, Permeability, and Charge State
Additional Information
How to Cite
Avdeef, A. (2003) Partitioning into Octanol, in Absorption and Drug Development: Solubility, Permeability, and Charge State, John Wiley & Sons, Inc., Hoboken, NJ, USA. doi: 10.1002/047145026X.ch4
Publication History
- Published Online: 8 OCT 2003
- Published Print: 15 AUG 2003
ISBN Information
Print ISBN: 9780471423652
Online ISBN: 9780471450269
- Summary
- Chapter
Keywords:
- log P;
- log D;
- ion-pair partitioning;
- micro-log P constants;
- HTS log P
Summary
This chapter surveys the experimental methods of measuring partition coefficients, log P and log D. It contains a description of the Dyrssen dual-phase potentiometric method, that truly is the ‘gold standard’ method for measuring log P of ionizable molecules, having the unique ten-orders of magnitude range (log P from −2 to +8). High-throughput methods are also described. A list of ‘gold standard’ quality partition coeffients is compiled.