4. Partitioning into Octanol

  1. Alex Avdeef

Published Online: 8 OCT 2003

DOI: 10.1002/047145026X.ch4

Absorption and Drug Development: Solubility, Permeability, and Charge State

Absorption and Drug Development: Solubility, Permeability, and Charge State

How to Cite

Avdeef, A. (2003) Partitioning into Octanol, in Absorption and Drug Development: Solubility, Permeability, and Charge State, John Wiley & Sons, Inc., Hoboken, NJ, USA. doi: 10.1002/047145026X.ch4

Author Information

  1. pION, Inc., USA

Publication History

  1. Published Online: 8 OCT 2003
  2. Published Print: 15 AUG 2003

ISBN Information

Print ISBN: 9780471423652

Online ISBN: 9780471450269

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Keywords:

  • log P;
  • log D;
  • ion-pair partitioning;
  • micro-log P constants;
  • HTS log P

Summary

This chapter surveys the experimental methods of measuring partition coefficients, log P and log D. It contains a description of the Dyrssen dual-phase potentiometric method, that truly is the ‘gold standard’ method for measuring log P of ionizable molecules, having the unique ten-orders of magnitude range (log P from −2 to +8). High-throughput methods are also described. A list of ‘gold standard’ quality partition coeffients is compiled.