6. Solubility

  1. Alex Avdeef

Published Online: 8 OCT 2003

DOI: 10.1002/047145026X.ch6

Absorption and Drug Development: Solubility, Permeability, and Charge State

Absorption and Drug Development: Solubility, Permeability, and Charge State

How to Cite

Avdeef, A. (2003) Solubility, in Absorption and Drug Development: Solubility, Permeability, and Charge State, John Wiley & Sons, Inc., Hoboken, NJ, USA. doi: 10.1002/047145026X.ch6

Author Information

  1. pION, Inc., USA

Publication History

  1. Published Online: 8 OCT 2003
  2. Published Print: 15 AUG 2003

ISBN Information

Print ISBN: 9780471423652

Online ISBN: 9780471450269

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Keywords:

  • aqueous solubility;
  • Gibb's pKa;
  • ‘delta-shift’ method;
  • kinetic log S;
  • HTS log S

Summary

This chapter dives into solubility measurements. A unique approach, based on the ‘dissolution template titration’ method, has demonstrated capabilities to measure solubilities as low as 1 nanogram per milliliter and as high as 50 mg/mL. Also, high-throughput microtitre plate UV methods for determining ‘thermodynamic’ solubility constants are described. At the ends of the chapters, an effort has been made to collect tables of critically-selected values of the constants of drug molecules, the best available values.