Chapter 6. Solubility
Published Online: 8 OCT 2003
DOI: 10.1002/047145026X.ch6
Copyright © 2003 John Wiley & Sons, Inc.
Book Title
Absorption and Drug Development: Solubility, Permeability, and Charge State
Additional Information
How to Cite
Avdeef, A. (2003) Solubility, in Absorption and Drug Development: Solubility, Permeability, and Charge State, John Wiley & Sons, Inc., Hoboken, NJ, USA. doi: 10.1002/047145026X.ch6
Publication History
- Published Online: 8 OCT 2003
- Published Print: 15 AUG 2003
ISBN Information
Print ISBN: 9780471423652
Online ISBN: 9780471450269
- Summary
- Chapter
Keywords:
- aqueous solubility;
- Gibb's pKa;
- ‘delta-shift’ method;
- kinetic log S;
- HTS log S
Summary
This chapter dives into solubility measurements. A unique approach, based on the ‘dissolution template titration’ method, has demonstrated capabilities to measure solubilities as low as 1 nanogram per milliliter and as high as 50 mg/mL. Also, high-throughput microtitre plate UV methods for determining ‘thermodynamic’ solubility constants are described. At the ends of the chapters, an effort has been made to collect tables of critically-selected values of the constants of drug molecules, the best available values.