7. Permeability

  1. Alex Avdeef

Published Online: 8 OCT 2003

DOI: 10.1002/047145026X.ch7

Absorption and Drug Development: Solubility, Permeability, and Charge State

Absorption and Drug Development: Solubility, Permeability, and Charge State

How to Cite

Avdeef, A. (2003) Permeability, in Absorption and Drug Development: Solubility, Permeability, and Charge State, John Wiley & Sons, Inc., Hoboken, NJ, USA. doi: 10.1002/047145026X.ch7

Author Information

  1. pION, Inc., USA

Publication History

  1. Published Online: 8 OCT 2003
  2. Published Print: 15 AUG 2003

ISBN Information

Print ISBN: 9780471423652

Online ISBN: 9780471450269

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Keywords:

  • PAMPA;
  • permeability;
  • lipid bilayers;
  • phospholipids;
  • black lipid membranes

Summary

This core chapter accounts for most of the newest technology related to the measurement of membrane permeability of molecules. The chapter considers in depth the PAMPA (parallel artificial membrane permeability assay) approach, the high-throughput method recently introduced by Manfred Kansy et al. of Hoffmann-La Roche. Chapter 7 is the first thorough account of the topic and takes up almost half of the book. The ‘double sink’ method is described. Original equations are derived, including those covering gradient-pH methods. Nearly 4000 original measurements are tabulated in the chapter.