Chapter 10. Intracellular Protein Trafficking
Published Online: 27 JAN 2004
DOI: 10.1002/047146158X.ch10
Copyright © 2004 John Wiley & Sons, Inc.
Book Title
Cell Biology: A Short Course, Second Edition
Additional Information
How to Cite
Bolsover, S. R., Hyams, J. S., Shephard, E. A., White, H. A. and Wiedemann, C. G. (2004) Intracellular Protein Trafficking, in Cell Biology: A Short Course, Second Edition, John Wiley & Sons, Inc., Hoboken, NJ, USA. doi: 10.1002/047146158X.ch10
Publication History
- Published Online: 27 JAN 2004
- Published Print: 14 NOV 2003
ISBN Information
Print ISBN: 9780471263937
Online ISBN: 9780471461586
- Summary
- Chapter
Keywords:
- gated transport;
- transmembrane translocation;
- vesicles;
- sorting signal;
- targeting sequence;
- GTPase;
- rough endoplasmic reticulum;
- Golgi complex;
- exocytosis
Summary
Newly synthesized proteins are delivered to their final destination by three different types of transport: gated transport of the folded protein, for example into the nucleus; translocation of the unfolded protein across one or more membranes, for example into the endoplasmic reticulum; or in vesicles along the route from endoplasmic reticulum to Golgi and beyond. Sorting signals on the protein bind to receptor proteins which in turn bind to translocation machinery. GTPases regulate many of these translocation steps.