Chapter 16. Intracellular Signaling

  1. Stephen R. Bolsover1,
  2. Jeremy S. Hyams2,
  3. Elizabeth A. Shephard3,
  4. Hugh A. White3,
  5. Claudia G. Wiedemann1

Published Online: 27 JAN 2004

DOI: 10.1002/047146158X.ch16

Book Title

Cell Biology: A Short Course, Second Edition

Cell Biology: A Short Course, Second Edition

Additional Information

How to Cite

Bolsover, S. R., Hyams, J. S., Shephard, E. A., White, H. A. and Wiedemann, C. G. (2004) Intracellular Signaling, in Cell Biology: A Short Course, Second Edition, John Wiley & Sons, Inc., Hoboken, NJ, USA. doi: 10.1002/047146158X.ch16

Author Information

  1. 1

    Department of Physiology, University College, London, UK

  2. 2

    Department of Biology, University College, London, UK

  3. 3

    Department of Biochemistry and Molecular Biology, University College, London, UK

Publication History

  1. Published Online: 27 JAN 2004
  2. Published Print: 14 NOV 2003

ISBN Information

Print ISBN: 9780471263937

Online ISBN: 9780471461586

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Keywords:

  • intracellular messenger;
  • calcium;
  • synapse;
  • inositol trisphosphate;
  • trimeric G protein;
  • cAMP;
  • cGMP;
  • receptor tyrosine kinase;
  • SH2;
  • Ras;
  • MAP kinase;
  • protein kinase B

Summary

In this chapter we describe how cells respond to external signals. Intracellular messengers such as calcium or cyclic AMP change concentration and activate downstream processes. Calcium ions can enter across the plasma membrane or be released from the endoplasmic reticulum. cAMP is generated from ATP. Receptor tyrosine kinases are activated by growth factors and other transmitters and activate pathways culminating in targets such as MAP kinase and protein kinase B.

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