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Analysis of Aqueous Solutions Using Electrospray Ionization Mass Spectrometry (ESI MS)

Physics and Chemistry of Water

  1. William Henderson

Published Online: 15 JUL 2005

DOI: 10.1002/047147844X.pc1507

Water Encyclopedia

Water Encyclopedia

How to Cite

Henderson, W. 2005. Analysis of Aqueous Solutions Using Electrospray Ionization Mass Spectrometry (ESI MS). Water Encyclopedia. 4:443–445.

Author Information

  1. University of Waikato, Hamilton, New Zealand

Publication History

  1. Published Online: 15 JUL 2005

Abstract

Electrospray ionization mass spectrometry (ESI MS) is a powerful analytical technique that can be used to analyze species dissolved in aqueous (and other) solutions. The technique operates by spraying a solution of the compound to be analyzed through a charged metal capillary, producing a spray of charged liquid droplets. These are then evaporated producing gas phase ions that undergo mass analysis. Any species that is ionic, or can generate a charged adduct by oxidation, protonation, deprotonation, and so on is potentially analyzable by ESI MS. Numerous applications of the technique in the analysis of biochemical and chemical substances in aqueous solutions have been developed.

Keywords:

  • electrospray ionization mass spectrometry;
  • solvation;
  • speciation;
  • applications;
  • isotopes