13. Telomere Structure and Function Provides Insights into the Generation of Genomic Instability and Carcinogenesis

  1. Gary S. Stein Ph.D.3 and
  2. Arthur B. Pardee Ph.D.4
  1. Colleen Fordyce1 and
  2. Thea D. Tlsty2

Published Online: 28 JAN 2005

DOI: 10.1002/0471656437.ch13

Cell Cycle and Growth Control: Biomolecular Regulation and Cancer, Second Edition

Cell Cycle and Growth Control: Biomolecular Regulation and Cancer, Second Edition

How to Cite

Fordyce, C. and Tlsty, T. D. (2005) Telomere Structure and Function Provides Insights into the Generation of Genomic Instability and Carcinogenesis, in Cell Cycle and Growth Control: Biomolecular Regulation and Cancer, Second Edition (eds G. S. Stein and A. B. Pardee), John Wiley & Sons, Inc., Hoboken, NJ, USA. doi: 10.1002/0471656437.ch13

Editor Information

  1. 3

    Department of Cell Biology and Cancer Center, University of Massachusetts Medical School, Worcester, Massachusetts, USA

  2. 4

    Department of Biological Chemistry and Molecular Pharmacology, Dana-Farber Cancer Institute, Boston, Massachusetts, USA

Author Information

  1. 1

    UCSF Comprehensive Cancer Center, University of California at San Francisco, San Francisco, California, USA

  2. 2

    Department of Pathology, University of California at San Francisco, San Francisco, California, USA

Publication History

  1. Published Online: 28 JAN 2005
  2. Published Print: 10 MAY 2004

ISBN Information

Print ISBN: 9780471250715

Online ISBN: 9780471656432

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Keywords:

  • genomic instability;
  • malfunctioning telomeres;
  • prognosis of carcinogenesis

Summary

This chapter contains sections titled:

  • Introduction

  • Telomere Composition and Structure

  • Malfunctioning Telomeres Facilitate Genomic Instability

  • Telomere Malfunction: An Early Event in Carcinogenesis?

  • Telomere Length and Prognosis in Cancer

  • New Methods for Telomere Quantification

  • Telomere Malfunction in Histologically Normal Cells

  • References