14. Immortalization by Sv40 Large T Antigen

  1. Gary S. Stein Ph.D.2 and
  2. Arthur B. Pardee Ph.D.3
  1. Rowena L. Lock,
  2. Silvia Benvenuti and
  3. Parmjit S. Jat

Published Online: 28 JAN 2005

DOI: 10.1002/0471656437.ch14

Cell Cycle and Growth Control: Biomolecular Regulation and Cancer, Second Edition

Cell Cycle and Growth Control: Biomolecular Regulation and Cancer, Second Edition

How to Cite

Lock, R. L., Benvenuti, S. and Jat, P. S. (2004) Immortalization by Sv40 Large T Antigen, in Cell Cycle and Growth Control: Biomolecular Regulation and Cancer, Second Edition (eds G. S. Stein and A. B. Pardee), John Wiley & Sons, Inc., Hoboken, NJ, USA. doi: 10.1002/0471656437.ch14

Editor Information

  1. 2

    Department of Cell Biology and Cancer Center, University of Massachusetts Medical School, Worcester, Massachusetts, USA

  2. 3

    Department of Biological Chemistry and Molecular Pharmacology, Dana-Farber Cancer Institute, Boston, Massachusetts, USA

Author Information

  1. Ludwig Institute for Cancer Research, Royal Free and University College School of Medicine, London, United Kingdom

Publication History

  1. Published Online: 28 JAN 2005
  2. Published Print: 10 MAY 2004

ISBN Information

Print ISBN: 9780471250715

Online ISBN: 9780471656432

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Keywords:

  • simian virus(SV40 T antigen);
  • immortalization;
  • insight into wild-type function of pathways

Summary

This chapter contains sections titled:

  • Introduction

  • Immortalization

  • SV40 Large T Antigen

  • The Retinoblastoma Family of Proteins

  • The P53 Protein

  • The J Domain and Hsc70

  • p300 and the CBP Family of Proteins

  • p63 and p73 Family of Proteins

  • Conclusions

  • References