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Mammary Gland Cancer

  1. Dalit Barkan,
  2. Cristina Montagna,
  3. Thomas Ried,
  4. Jeffrey E. Green

Published Online: 15 OCT 2004

DOI: 10.1002/0471675067.mmc007

Mouse Models of Human Cancer

Mouse Models of Human Cancer

How to Cite

Barkan, D., Montagna, C., Ried, T. and Green, J. E. 2004. Mammary Gland Cancer. Mouse Models of Human Cancer. .

Author Information

  1. National Cancer Institute, National Institutes of Health, Bethesda, Maryland, United States

Publication History

  1. Published Online: 15 OCT 2004

Abstract

It has been 20 years since the first genetically engineered mouse model of mammary cancer was published (Stewart et al., 1984) using transgenic technology. Since the first report there have been well over 100 mouse models of mammary cancer developed which have provided critical insights into the functions of numerous genes involved in mammary oncogenesis. Advances in manipulating the mouse genome have provided the technology to induce mammary cancers in mice that arise from genetic mutations that have been identified in human cancer, thus generating models based upon molecular lesions relevant to the human disease. Recent work has focused on validating these models as systems which represent, at least in part, various aspects of the human disease and which may be used for preclinical testing of novel therapies. The challenge remains to establish the predictive value of such models for chemoprevention and therapeutic response for treating human breast cancer.

Keywords:

  • mammary gland cancer;
  • human breast cancer;
  • genomic changes;
  • molecular changes;
  • breast cancer lesions;
  • prognostic markers;
  • hormone responsiveness;
  • metastases;
  • imaging;
  • chemoprevention;
  • retinoids;
  • gene expression profiling