4. Organotin Macromolecules as Anticancer Drugs

  1. Alaa S. Abd-El-Aziz2,
  2. Charles E. Carraher Jr.3,
  3. Charles U. Pittman Jr.4,
  4. John E. Sheats5 and
  5. Martel Zeldin6
  1. Charles E. Carraher Jr.3 and
  2. Deborah Siegmann-Louda1

Published Online: 28 JUL 2004

DOI: 10.1002/0471683779.ch4

Macromolecules Containing Metal and Metal-Like Elements: Biomedical Applications, Volume 3

Macromolecules Containing Metal and Metal-Like Elements: Biomedical Applications, Volume 3

How to Cite

Carraher, C. E. and Siegmann-Louda, D. (2004) Organotin Macromolecules as Anticancer Drugs, in Macromolecules Containing Metal and Metal-Like Elements: Biomedical Applications, Volume 3 (eds A. S. Abd-El-Aziz, C. E. Carraher, C. U. Pittman, J. E. Sheats and M. Zeldin), John Wiley & Sons, Inc., Hoboken, NJ, USA. doi: 10.1002/0471683779.ch4

Editor Information

  1. 2

    Department of Chemistry, The University of Winnipeg, Winnipeg, Manitoba, Canada

  2. 3

    Department of Chemistry and Biochemistry, Florida Atlantic University, Boca Raton, Florida and Florida Center for Environmental Studies, Palm Beach Gardens, Florida, USA

  3. 4

    Department of Chemistry, Mississippi State University, Mississippi State, Mississippi, USA

  4. 5

    Department of Chemistry, Rider University, Lawrenceville, New Jersey, USA

  5. 6

    Department of Chemistry, Hobart and William Smith Colleges, Geneva, New York, USA

Author Information

  1. 1

    Florida Atlantic University, Boca Raton, FL 33431, USA

  2. 3

    Department of Chemistry and Biochemistry, Florida Atlantic University, Boca Raton, Florida and Florida Center for Environmental Studies, Palm Beach Gardens, Florida, USA

Publication History

  1. Published Online: 28 JUL 2004
  2. Published Print: 18 JUN 2004

ISBN Information

Print ISBN: 9780471667377

Online ISBN: 9780471683773

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Keywords:

  • anticancer;
  • cancer;
  • organotin polymers;
  • anticancer mechanism;
  • structure property relationships;
  • cisplatin;
  • organotin compounds;
  • dibutyltin;
  • diphenyltin;
  • Balb 3T3 cells;
  • breast cancer;
  • norfloxacin;
  • ciprofloxacin;
  • kinetin

Summary

While much of the initial effort with organotin polymers focused on their use as antibacterial and antifungal agents, much recent work has focused on their use in fighting cancer. This effort is reviewed along with looking at the mechanism of action in fighting cancer including small molecule models. The case for utilizing organotin polymers in fighting cancer is described. Future directions are also given.