5. Organotin Oligomeric Drugs Containing the Antiviral Agent Acyclovir

  1. Alaa S. Abd-El-Aziz2,
  2. Charles E. Carraher Jr.3,
  3. Charles U. Pittman Jr.4,
  4. John E. Sheats5 and
  5. Martel Zeldin6
  1. Charles E. Carraher Jr.3 and
  2. Robert E. Bleicher1

Published Online: 28 JUL 2004

DOI: 10.1002/0471683779.ch5

Macromolecules Containing Metal and Metal-Like Elements: Biomedical Applications, Volume 3

Macromolecules Containing Metal and Metal-Like Elements: Biomedical Applications, Volume 3

How to Cite

Carraher, C. E. and Bleicher, R. E. (2004) Organotin Oligomeric Drugs Containing the Antiviral Agent Acyclovir, in Macromolecules Containing Metal and Metal-Like Elements: Biomedical Applications, Volume 3 (eds A. S. Abd-El-Aziz, C. E. Carraher, C. U. Pittman, J. E. Sheats and M. Zeldin), John Wiley & Sons, Inc., Hoboken, NJ, USA. doi: 10.1002/0471683779.ch5

Editor Information

  1. 2

    Department of Chemistry, The University of Winnipeg, Winnipeg, Manitoba, Canada

  2. 3

    Department of Chemistry and Biochemistry, Florida Atlantic University, Boca Raton, Florida and Florida Center for Environmental Studies, Palm Beach Gardens, Florida, USA

  3. 4

    Department of Chemistry, Mississippi State University, Mississippi State, Mississippi, USA

  4. 5

    Department of Chemistry, Rider University, Lawrenceville, New Jersey, USA

  5. 6

    Department of Chemistry, Hobart and William Smith Colleges, Geneva, New York, USA

Author Information

  1. 1

    California State University Channel Islands, Camarillo, CA 93012, USA

  2. 3

    Department of Chemistry and Biochemistry, Florida Atlantic University, Boca Raton, Florida and Florida Center for Environmental Studies, Palm Beach Gardens, Florida, USA

Publication History

  1. Published Online: 28 JUL 2004
  2. Published Print: 18 JUN 2004

ISBN Information

Print ISBN: 9780471667377

Online ISBN: 9780471683773

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Keywords:

  • acyclovir;
  • organotin;
  • antiviral;
  • mass spectrometry;
  • polyorganotin ether amines;
  • interfacial polymerization;
  • interfacial polycondensation;
  • bioactivity

Summary

The initial synthesis of organotin polymers containing the antiviral acyclovir is described. Structural analysis is described in some detail including mass spectrometry, molecular weight, and infrared analysis. The mechanism of polymer formation is discussed. The general activity of both acyclovir and organotin compounds is reviewed.