6. Polymeric Ferrocene Conjugates as Antiproliferative Agents

  1. Alaa S. Abd-El-Aziz2,
  2. Charles E. Carraher Jr.3,
  3. Charles U. Pittman Jr.4,
  4. John E. Sheats5 and
  5. Martel Zeldin6
  1. Eberhard W. Neuse

Published Online: 28 JUL 2004

DOI: 10.1002/0471683779.ch6

Macromolecules Containing Metal and Metal-Like Elements: Biomedical Applications, Volume 3

Macromolecules Containing Metal and Metal-Like Elements: Biomedical Applications, Volume 3

How to Cite

Neuse, E. W. (2004) Polymeric Ferrocene Conjugates as Antiproliferative Agents, in Macromolecules Containing Metal and Metal-Like Elements: Biomedical Applications, Volume 3 (eds A. S. Abd-El-Aziz, C. E. Carraher, C. U. Pittman, J. E. Sheats and M. Zeldin), John Wiley & Sons, Inc., Hoboken, NJ, USA. doi: 10.1002/0471683779.ch6

Editor Information

  1. 2

    Department of Chemistry, The University of Winnipeg, Winnipeg, Manitoba, Canada

  2. 3

    Department of Chemistry and Biochemistry, Florida Atlantic University, Boca Raton, Florida and Florida Center for Environmental Studies, Palm Beach Gardens, Florida, USA

  3. 4

    Department of Chemistry, Mississippi State University, Mississippi State, Mississippi, USA

  4. 5

    Department of Chemistry, Rider University, Lawrenceville, New Jersey, USA

  5. 6

    Department of Chemistry, Hobart and William Smith Colleges, Geneva, New York, USA

Author Information

  1. School of Chemistry, University of the Witwatersrand, Johannesburg, WITS 2050, South Africa

Publication History

  1. Published Online: 28 JUL 2004
  2. Published Print: 18 JUN 2004

ISBN Information

Print ISBN: 9780471667377

Online ISBN: 9780471683773

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Keywords:

  • ferrocene;
  • polymeric ferrocene;
  • antiproliferative agents;
  • antineoplastic

Summary

Ferrocene, di-(05-cyclopentadienyl)iron(II), a key representative of the class of organometallic compounds known as metallocenes, has found numerous divergent applications in science and technology. The compound owes this multivaried behavior pattern largely to its unusual electronic structure and resultant oxidation-reduction properties. Attracted by the challenges offered in the realm of the biosciences, a major stream of investigative activities, as shown in Section II of this chapter, has flowed into biochemistry, where evidence of significant interaction of the nonpolymeric ferrocene–ferricenium system with the biological environment has been provided. In more recent years, the biomedical target presented by the proliferative cancer cell has emerged as a particularly rewarding topic in metallocene research. We have seen that strong antiproliferative, i.e. cell growth-inhibiting action, can be observed as cultured cancer cells are exposed in vitro to selected water-soluble ferrocene derivatives, especially those comprising the metallocene in its Fe(III) (ferricenium) state. We have also seen that excellent antineoplastic activity is evident even in certain in vivo systems.