7. Polymeric Platinum-Containing Drugs in the Treatment of Cancer
- Alaa S. Abd-El-Aziz2,
- Charles E. Carraher Jr.3,
- Charles U. Pittman Jr.4,
- John E. Sheats5,
- Martel Zeldin6
Published Online: 28 JUL 2004
DOI: 10.1002/0471683779.ch7
Copyright © 2004 John Wiley & Sons, Inc.
Book Title
Macromolecules Containing Metal and Metal-Like Elements: Biomedical Applications, Volume 3
Additional Information
How to Cite
Siegmann-Louda, D. W. and Carraher, C. E. (2004) Polymeric Platinum-Containing Drugs in the Treatment of Cancer, in Macromolecules Containing Metal and Metal-Like Elements: Biomedical Applications, Volume 3 (eds A. S. Abd-El-Aziz, C. E. Carraher, C. U. Pittman, J. E. Sheats and M. Zeldin), John Wiley & Sons, Inc., Hoboken, NJ, USA. doi: 10.1002/0471683779.ch7
Editor Information
- 2
Department of Chemistry, The University of Winnipeg, Winnipeg, Manitoba, Canada
- 3
Department of Chemistry and Biochemistry, Florida Atlantic University, Boca Raton, Florida and Florida Center for Environmental Studies, Palm Beach Gardens, Florida, USA
- 4
Department of Chemistry, Mississippi State University, Mississippi State, Mississippi, USA
- 5
Department of Chemistry, Rider University, Lawrenceville, New Jersey, USA
- 6
Department of Chemistry, Hobart and William Smith Colleges, Geneva, New York, USA
Publication History
- Published Online: 28 JUL 2004
- Published Print: 18 JUN 2004
ISBN Information
Print ISBN: 9780471667377
Online ISBN: 9780471683773
- Summary
- Chapter
Keywords:
- platinum-containing polyphosphazenes;
- cisplatin;
- polymeric cisplatin;
- biofission;
- platinum-carrier-bound;
- anchored platinum drugs;
- cancer;
- anticancer;
- carboplatinum;
- CDDP;
- cis-DDP;
- platinum-containing anticancer agents
Summary
Malignant neoplasms, cancers, are the second leading cause of death in the United States. In 1964 Rosenberg and co-workers discovered that in the presence of platinum electrodes E. coli failed to divide but continued growing, giving filamentous cells. The cause of the inhibition of cell division was found to be cis-diaminedichloroplatinum (II), also known as cis-DDP and cisplatin. Cisplatin is the most widely used anticancer agent. The mechanism of action of cisplatin is reviewed. The synthesis and use of polymeric derivatives of cisplatin is reviewed as is the synthesis and biological use of polymeric derivatives of carboplatinum, the two commercially used anticancer drugs. The review includes platinum-bound and platinum-backbone drugs. The argument for the use of platinum-bound and platinum-backbone drugs is given and discussed.