7. Polymeric Platinum-Containing Drugs in the Treatment of Cancer

  1. Alaa S. Abd-El-Aziz2,
  2. Charles E. Carraher Jr.3,
  3. Charles U. Pittman Jr.4,
  4. John E. Sheats5 and
  5. Martel Zeldin6
  1. Deborah W. Siegmann-Louda1 and
  2. Charles E. Carraher Jr.3

Published Online: 28 JUL 2004

DOI: 10.1002/0471683779.ch7

Macromolecules Containing Metal and Metal-Like Elements: Biomedical Applications, Volume 3

Macromolecules Containing Metal and Metal-Like Elements: Biomedical Applications, Volume 3

How to Cite

Siegmann-Louda, D. W. and Carraher, C. E. (2004) Polymeric Platinum-Containing Drugs in the Treatment of Cancer, in Macromolecules Containing Metal and Metal-Like Elements: Biomedical Applications, Volume 3 (eds A. S. Abd-El-Aziz, C. E. Carraher, C. U. Pittman, J. E. Sheats and M. Zeldin), John Wiley & Sons, Inc., Hoboken, NJ, USA. doi: 10.1002/0471683779.ch7

Editor Information

  1. 2

    Department of Chemistry, The University of Winnipeg, Winnipeg, Manitoba, Canada

  2. 3

    Department of Chemistry and Biochemistry, Florida Atlantic University, Boca Raton, Florida and Florida Center for Environmental Studies, Palm Beach Gardens, Florida, USA

  3. 4

    Department of Chemistry, Mississippi State University, Mississippi State, Mississippi, USA

  4. 5

    Department of Chemistry, Rider University, Lawrenceville, New Jersey, USA

  5. 6

    Department of Chemistry, Hobart and William Smith Colleges, Geneva, New York, USA

Author Information

  1. 1

    Florida Atlantic University, Boca Raton, FL 33431, USA

  2. 3

    Department of Chemistry and Biochemistry, Florida Atlantic University, Boca Raton, Florida and Florida Center for Environmental Studies, Palm Beach Gardens, Florida, USA

Publication History

  1. Published Online: 28 JUL 2004
  2. Published Print: 18 JUN 2004

ISBN Information

Print ISBN: 9780471667377

Online ISBN: 9780471683773

SEARCH

Keywords:

  • platinum-containing polyphosphazenes;
  • cisplatin;
  • polymeric cisplatin;
  • biofission;
  • platinum-carrier-bound;
  • anchored platinum drugs;
  • cancer;
  • anticancer;
  • carboplatinum;
  • CDDP;
  • cis-DDP;
  • platinum-containing anticancer agents

Summary

Malignant neoplasms, cancers, are the second leading cause of death in the United States. In 1964 Rosenberg and co-workers discovered that in the presence of platinum electrodes E. coli failed to divide but continued growing, giving filamentous cells. The cause of the inhibition of cell division was found to be cis-diaminedichloroplatinum (II), also known as cis-DDP and cisplatin. Cisplatin is the most widely used anticancer agent. The mechanism of action of cisplatin is reviewed. The synthesis and use of polymeric derivatives of cisplatin is reviewed as is the synthesis and biological use of polymeric derivatives of carboplatinum, the two commercially used anticancer drugs. The review includes platinum-bound and platinum-backbone drugs. The argument for the use of platinum-bound and platinum-backbone drugs is given and discussed.