Chapter 9. Other Biopolymers and Synthetic Polymers of Biological Interest

  1. Igor A. Kaltashov and
  2. Stephen J. Eyles

Published Online: 27 JAN 2005

DOI: 10.1002/0471705179.ch9

Mass Spectrometry in Biophysics: Conformation and Dynamics of Biomolecules

Mass Spectrometry in Biophysics: Conformation and Dynamics of Biomolecules

How to Cite

Kaltashov, I. A. and Eyles, S. J. (2005) Other Biopolymers and Synthetic Polymers of Biological Interest, in Mass Spectrometry in Biophysics: Conformation and Dynamics of Biomolecules, John Wiley & Sons, Inc., Hoboken, NJ, USA. doi: 10.1002/0471705179.ch9

Author Information

  1. University of Massachusetts at Amherst, USA

Publication History

  1. Published Online: 27 JAN 2005
  2. Published Print: 6 APR 2005

Book Series:

  1. Wiley-Interscience Series in Mass Spectrometry

Book Series Editors:

  1. Dominic M. Desiderio2 and
  2. Nico M. M. Nibbering3

Series Editor Information

  1. 2

    Departments of Neurology and Biochemistry, University of Tennessee Health Science Center, USA

  2. 3

    Vrije Universiteit Amsterdam, The Netherlands

ISBN Information

Print ISBN: 9780471456025

Online ISBN: 9780471705178

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Keywords:

  • oligonucleotides;
  • DNA;
  • RNA;
  • carbohydrates;
  • structural proteins;
  • synthetic polymers

Summary

So far, the majority of applications of MS methods to study biomolecular structure and dynamics have focused on proteins. However, oligonucleotides and carbohydrates are also becoming targets of such studies. Unfortunately, many methods developed for proteins can not be directly applied to study dynamics of glycans and oligonucleotides (e.g., due to much higher rates of labile hydrogen exchange). In this chapter we will focus primarily on several experimental methods developed specifically to probe the behavior of nonprotein biopolymers. This discussion will be extended to consider uses of mass spectrometry to study the behavior of polymers of nonbiological origin.