Chapter 5. Sample Preparation and Separations Development

  1. Marvin C. McMaster

Published Online: 19 JUL 2005

DOI: 10.1002/0471736589.ch5

LC/MS: A Practical User's Guide

LC/MS: A Practical User's Guide

How to Cite

McMaster, M. C. (2005) Sample Preparation and Separations Development, in LC/MS: A Practical User's Guide, John Wiley & Sons, Inc., Hoboken, NJ, USA. doi: 10.1002/0471736589.ch5

Author Information

  1. Florissant, Missouri, USA

Publication History

  1. Published Online: 19 JUL 2005
  2. Published Print: 12 AUG 2005

ISBN Information

Print ISBN: 9780471655312

Online ISBN: 9780471736585



  • phenyl–silica columns;
  • tubing line filters;
  • sample filtration and extraction (SFE)


This chapter contains sections titled:

  • Mobile-Phase Preparation

  • Mobile-Phase pH Control Using Buffers

  • Sample Preparation

  • Cartridge Column Cleanup

  • On-Column Sample Concentration

  • Isocratic and Gradient Methods Development

  • Automated Methods Development