Chapter 12. Enzymes Lose Binding Affinity (Increased Km) for Coenzymes and Substrates with Age: A Strategy for Remediation

  1. Jim Kaput2,3,4 and
  2. Raymond L. Rodriguez Ph.D.2,5,6
  1. Bruce N. Ames,
  2. Jung H. Suh and
  3. Jiankang Liu

Published Online: 10 MAY 2006

DOI: 10.1002/0471781797.ch12

Nutritional Genomics: Discovering the Path to Personalized Nutrition

Nutritional Genomics: Discovering the Path to Personalized Nutrition

How to Cite

Ames, B. N., Suh, J. H. and Liu, J. (2006) Enzymes Lose Binding Affinity (Increased Km) for Coenzymes and Substrates with Age: A Strategy for Remediation, in Nutritional Genomics: Discovering the Path to Personalized Nutrition (eds J. Kaput and R. L. Rodriguez), John Wiley & Sons, Inc., Hoboken, NJ, USA. doi: 10.1002/0471781797.ch12

Editor Information

  1. 2

    Center of Excellence in Nutritional Genomics, University of California–Davis, Davis, California, USA

  2. 3

    NutraGenomics, Chicago, Illinois, USA

  3. 4

    Laboratory of Nutrigenomic Medicine, University of Illinois, Chicago, Illinois, USA

  4. 5

    Section of Molecular and Cellular Biology, University of California–Davis, Davis, California, USA

  5. 6

    Bioinformatics Shared Resources Core, University of California–Davis, Davis, California, USA

Author Information

  1. Nutrition and Metabolism Center, Children's Hospital Oakland Research Unit, Oakland, California and University of California–Berkeley, Berkeley, California, USA

Publication History

  1. Published Online: 10 MAY 2006
  2. Published Print: 24 MAR 2006

ISBN Information

Print ISBN: 9780471683193

Online ISBN: 9780471781790

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Keywords:

  • mitochondrial protein deformation;
  • mitochondrial decay with age;
  • remediation and high B vitamin intake

Summary

This chapter contains sections titled:

  • Introduction

  • Remediation by High B Vitamin Intake of Variant Enzymes with Poor Binding Affinity (Km) for Coenzymes

  • Deformation of Proteins in Mitochondria with Aging

  • Nonmitochondrial Enzymes that are Deformed with Age

  • Conclusion

  • Acknowledgments

  • References