Chapter 9. Molecular Mechanisms of Longevity Regulation and Calorie Restriction

  1. Jim Kaput2,3,4 and
  2. Raymond L. Rodriguez Ph.D.2,5,6
  1. Su-Ju Lin

Published Online: 10 MAY 2006

DOI: 10.1002/0471781797.ch9

Nutritional Genomics: Discovering the Path to Personalized Nutrition

Nutritional Genomics: Discovering the Path to Personalized Nutrition

How to Cite

Lin, S.-J. (2006) Molecular Mechanisms of Longevity Regulation and Calorie Restriction, in Nutritional Genomics: Discovering the Path to Personalized Nutrition (eds J. Kaput and R. L. Rodriguez), John Wiley & Sons, Inc., Hoboken, NJ, USA. doi: 10.1002/0471781797.ch9

Editor Information

  1. 2

    Center of Excellence in Nutritional Genomics, University of California–Davis, Davis, California, USA

  2. 3

    NutraGenomics, Chicago, Illinois, USA

  3. 4

    Laboratory of Nutrigenomic Medicine, University of Illinois, Chicago, Illinois, USA

  4. 5

    Section of Molecular and Cellular Biology, University of California–Davis, Davis, California, USA

  5. 6

    Bioinformatics Shared Resources Core, University of California–Davis, Davis, California, USA

Author Information

  1. Section of Microbiology, College of Biological Sciences, University of California–Davis, Davis, California, USA

Publication History

  1. Published Online: 10 MAY 2006
  2. Published Print: 24 MAR 2006

ISBN Information

Print ISBN: 9780471683193

Online ISBN: 9780471781790

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Keywords:

  • longevity regulation and calorie restriction;
  • calorie restriction molecular mechanisms;
  • Sir2 interacting proteins and longevity in mammals

Summary

This chapter contains sections titled:

  • Introduction

  • A Conserved Longevity Factor, Sir2

  • Molecular Mechanisms of Calorie Restriction

  • Role of NAD/NADH Ratio in Aging and Human Diseases

  • Possible CR Mimetics—Small Molecules that Regulate Sir2 Activity

  • Molecular Targets of Sir2 Proteins in Mammals

  • A Possibly Conserved Longevity Pathway

  • Applications to Nutritional Genomics

  • References