A cellular and malignant blue nevus: A light and electron microscopic study

Authors

  • Leonard P. Merkow MD, PhD,

    Corresponding author
    1. Department of Surgical Pathology, William H. Singer Memorial Research Institute, and The Division of Surgery, Allegheny General Hospital, Pittsburgh, Pa. 15212
    • William H. Singer Memorial Research Institute of the Allegheny General Hospital, 320 East North Ave., Pittsburgh, Pa., 15212
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  • Robert C. Burt MD,

    1. Department of Surgical Pathology, William H. Singer Memorial Research Institute, and The Division of Surgery, Allegheny General Hospital, Pittsburgh, Pa. 15212
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  • David W. Hayeslip MD,

    1. Department of Surgical Pathology, William H. Singer Memorial Research Institute, and The Division of Surgery, Allegheny General Hospital, Pittsburgh, Pa. 15212
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  • Frank J. Newton MD,

    1. Department of Surgical Pathology, William H. Singer Memorial Research Institute, and The Division of Surgery, Allegheny General Hospital, Pittsburgh, Pa. 15212
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  • Malcolm Slifkin PhD,

    1. Department of Surgical Pathology, William H. Singer Memorial Research Institute, and The Division of Surgery, Allegheny General Hospital, Pittsburgh, Pa. 15212
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  • Matias Pardo

    1. Department of Surgical Pathology, William H. Singer Memorial Research Institute, and The Division of Surgery, Allegheny General Hospital, Pittsburgh, Pa. 15212
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Abstract

A rare malignant blue nevus resected from the back of a 34-year-old Caucasian woman is reported. Histopathologic examination showed the presence of a CBN as well as MBN. The CBN elements of this lesion showed the characteristic prominent neural type fascicles intertwined with melanocytes. The deeper regions of this skin neoplasm showed considerable variation in histopathologic patterns. Metastascs to the axillary lymph nodes and multiple subdermal soft tissue sites, invasion of the underlying skeletal muscle, and several recurrences in the chest wall indicate that this neoplasm is malignant, though of a lower order than a malignant melanoma. The ultrastructural characteristics of neoplastic cells indicate that this neoplasm is of Schwann cell origin.

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