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Clinical Associate in Obstetrics and Gynecology, Harvard Medical School.
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Adenocarcinoma of the vagina in adolescence. A report of 7 cases including 6 clear-cell carcinomas (so-called mesonephromas)
Article first published online: 28 JUN 2006
DOI: 10.1002/1097-0142(197004)25:4<745::AID-CNCR2820250402>3.0.CO;2-2
Copyright © 1970 American Cancer Society
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How to Cite
Herbst, A. L. and Scully, R. E. (1970), Adenocarcinoma of the vagina in adolescence. A report of 7 cases including 6 clear-cell carcinomas (so-called mesonephromas). Cancer, 25: 745–757. doi: 10.1002/1097-0142(197004)25:4<745::AID-CNCR2820250402>3.0.CO;2-2
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Clinical Associate in Obstetrics and Gynecology, Harvard Medical School.
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Associate Professor of Pathology at Massachusetts General Hospital, Harvard Medical School.
Publication History
- Issue published online: 28 JUN 2006
- Article first published online: 28 JUN 2006
- Manuscript Received: 23 SEP 1969
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Abstract
Seven cases of adenocarcinoma of the vagina occurring in young women 15 to 22 years of age are reported. Six sought medical advice because of abnormal bleeding, which was assumed to be due to anovulation. Hormonal therapy delayed the correct diagnosis, which was not made until vaginal examination was performed. Vaginal smears contained rare suspicious or malignant cells in 3 cases but were negative in 3 others, indicating that cytologic examination is unreliable as a diagnostic aid. Six of the tumors were clear-cell carcinomas, or so-called mesonephromas, and one was an endometrioid carcinoma. The frequent presence of vaginal adenosis and other evidence suggested that the clear-cell carcinomas were of müllerian and not mesonephric origin. Although the follow-up has not been long, radical surgery with vaginal replacement and ovarian conservation appears to have been a safe and effective method of therapy.