Invasion of the brain by a cellular blue nevus of the scalp.A case report with light and electron microscopic studies

Authors

  • Gerald D. Silverberg MD,

    Corresponding author
    1. Stanford University Hospital and School of Medicine, Stanford, Calif.
    • Gerald D. Silverberg, MD, Division of Neurosurgery, Stanford University Hospital and School of Medicine, Stanford, Calif. 94305
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    • Resident in Neurosurgery.

  • Marshall E. Kadin MD,

    1. Stanford University Hospital and School of Medicine, Stanford, Calif.
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    • Post-Doctoral fellow in Pathology.

  • Ronald F. Dorfman MB, BCh,

    1. Stanford University Hospital and School of Medicine, Stanford, Calif.
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    • Associate Professor of Pathology.

  • John W. Hanbery MD,

    1. Stanford University Hospital and School of Medicine, Stanford, Calif.
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    • Professor of Neurosurgery.

  • Donald J. Prolo MD

    1. Stanford University Hospital and School of Medicine, Stanford, Calif.
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    • Resident in Neurosurgery.


Abstract

Repeated biopsies of a large pigmented lesion of the scalp of a young boy over a six-year period showed the characteristic features of a cellular blue nevus. Recent severe neurologic symptoms necessitated more radical surgical intervention. This disclosed focal invasion of the underlying skull, meninges, and brain. Apart from focal necrosis and multiple nucleoli in the most recent surgical specimen, the histologic features of the lesion have remained constant, despite its locally aggressive behavior. Electron microscopic studies demonstrated distinctive nucleolar configurations not previously reported.

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